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Myth: You need to stop tirzepatide at the first sign of heartburn

Patients with dyslipidaemia requiring pharmacological intervention should be managed according to NICE guidance (NG238), which typically recommends statins as first-line therapy

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The addition of glucagon receptor agonism is thought to increase energy expenditure and promote hepatic fat breakdown

Whether these results hold across all Phase 3 TRIUMPH trials remains to be seen, but the consistency between Phase 2 and TRIUMPH-4 data builds confidence

Gastroenterology 163 , 386402