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GPX-1 prevents the formation of DNA mutations and suppresses carcinogenic potential

Interestingly, this tamoxifen-induced differentiation occurs in a PKC signaling independent-manner, and not only by activation of classical estrogen receptors but also by activation of GPER-1 (Gonzalez et al., 2016)

Concerns about IGF-1 include potential effects on cancer risk, acromegalic changes with chronic elevation, and metabolic disruption

Khotskaya YB, Holla VR, Farago AF, Mills Shaw KR, Meric-Bernstam F, Hong DS (2017) Targeting TRK family proteins in cancer