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En mujeres con sobrepeso, obesidad, RI y/u otros factores de riesgo para desarrollar SOP, el incremento de insulina asociado a la pubertad puede precipitar la aparicin de las manifestaciones clnicas del SOP, como lo son en las adolescentes (hirsutismo persistente y progresivo, acn grave o comedoniano, amenorrea o irregularidades menstruales), que debern distinguirse de los cambios fisiolgicos propios de la adolescencia, lo cual hace ms complejo el diagnstico en esta etapa de la vida 29 - 30

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