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FDA reviewers cited weak clinical evidence, substance-characterization concerns, differences between studied and proposed administration routes, and the availability of approved treatments for conditions discussed during the review

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A recall issued by Health Canada in 2019 specifically highlights MK-677 as not being authorized in Canada for any use

This includes IV therapy administration, peptide prescribing, and hormone optimization protocols

This is mainly through the adrenal glands producing stress hormones such as cortisol

Oral delivery provides an entry point to explore the category without the commitment and technical demands of injectable protocols