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Important Precautions for Safe Use 15.1 Gradual Dose Escalation to Minimize Side Effects A stepwise titration strategy reduces gastrointestinal intolerance and enhances patient adherence

doi: 10.1038/nature15739

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Prepared by the editors of Harvard Health Publishing in consultation with Chika V

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Significant weight loss (at least 10% of body weight) reduces HbA1c, blood pressure, lipid levels [88], and the incidence of MACEs including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, and hospitalized angina by up to 21% in T2DM patients