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Nitro reductase is reported to be overexpressed in bio-reductive hypoxic cancer, and its expression level is directly related to the hypoxic status

Glutathione deficiency is associated with aging, diabetes, neurodegenerative disorders, and more

In other embodiments, useful auris-acceptable pharmaceutical formulations also include one or more pH adjusting agents or buffering agents to provide an endolymph or perilymph suitable pH

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GPX8 is similar to GPX7 because both have low glutathione peroxidase (GSH) activity, mainly due to the lack of domains bound to GSH

Bacterial cells were collected by centrifugation at 4,000 g for 20 min at 4 C and the cell pellet was resuspended in buffer (50 mM NaH 2 PO 4 and 300 mM NaCl, pH 6.0)