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Furthermore, the relevance of TRPs in NP will remain elusive until experimental studies (including knockdown or knockout animal models) demonstrate that an increase in TRP activity by exogenous TRP activators produces NP

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Neurobiol Dis (2012) 48:10214.10.1016/j.nbd.2012.06.007 35 NapoliERoss-IntaCWongSHungCFujisawaYSakaguchiDet alMitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53