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A rare case of graves disease after SARS-CoV-2 vaccine: is it an adjuvant effect

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The main extra consideration with the injection is the chance of mild injection site reactions

Flohes objection points out that the rate constants for the spontaneous reactions of inter-conversion of thiol disulfides are negligibly small, with respect to those necessary to explain biological processes, and therefore the intervention of the enzymatic systems is of a crucial importance in determining the behavior of a biological system