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Furthermore, the crosstalk between the three in different organizations or cells, the manner in which this crosstalk occurs, and the specific molecular mechanisms involved require further in-depth study

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NADPH-dependent disulfide reductases Although there are hundreds of different NADPH-dependent enzymes in biology, each of which has the ability to use electrons extracted from NADPH to reduce specific organic or inorganic substrates, only two small groups of these enzymes, the Trx-disulfide reductases (TrxRs) and the glutathione-disulfide (GSSG)-reductases (Gsrs), can reduce an intracellular disulfide [42]

doi: 10.1016/j.drup.2021.100797 12 PrioloCPyneSRoseJReganERZadraGPhotopoulosCet al