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Splitting a dose reduces peak concentration, which weakens appetite suppression and can diminish weight loss results by up to 2030% compared to full-dose therapy

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Thirdly, consistent with the occurrence of side effects in the GLP-1 RAs, gastrointestinal disorders and hypoglycemia were the most common adverse events

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Effect of sodium-glucose co-transporter 2 inhibitors on lipid profile: A systematic review and meta-analysis of 48 randomized controlled trials