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Selank, built from an immune peptide, is framed as an anxiolytic that tunes GABA and serotonin signaling without the sedation or dependence of benzodiazepines, which is why its flagship Russian trial targeted generalized anxiety

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First, the human RCT footprint is thinner than the mechanism literature

The open-label design of this trial presumably contributed to the very high response rates seen with infliximab therapy, rates that are much higher than those that have been seen in other trials of TNF inhibitors in PsA

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The unique combination in Klow may allow for comparative study across mechanisms like cell signaling, cytokine dynamics, and protein synthesis pathways