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101 Phosphorylation of fumarate hydratase (FH) by p38 in response to TGF- signaling leads to its binding to the transcription factor CSL/p53 complex on the p21 promoter, which inhibits histone H3K36 demethylation, enhances p21 transcription, and induces cell growth arrest

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Unlike semaglutide, which targets only GLP-1 receptors, tirzepatide is a dual agonist that activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

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Liraglutide improves vascular dysfunction by regulating a cAMP-independent PKA-AMPK pathway in perivascular adipose tissue in obese mice