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B.SlomaA.HermannT.TheriaultK.ZachgoE.ErdenbergerT.et al (1999a)

DAO uses copper as a cofactor and requires vitamin B6 (in its P5P form) to function optimally. 24 Multiple SNPs in AOC1 have been associated with significantly reduced DAO activity and histamine intolerance

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These positive effects are due to their ability to reduce inflammation, protect nerve cells, aid in weight loss and safeguard the blood vessels [1618]

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Patients should also be taught simple strategies to reduce side effects, such as drinking more fluids, increasing fiber slowly, and adjusting food choices when symptoms flare