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Reducing that complex preparation to a single four-residue sequence, Ala-Glu-Asp-Gly, made it possible to study a reproducible molecule rather than a variable extract, and this is part of why Epithalon became the most-referenced compound in the short peptide bioregulator field

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However, current investigations have expanded to include a variety of diseases, such as neurodegenerative diseases [9], rheumatoid arthritis [10], cardiovascular diseases [11], infectious diseases [12], and aging-related diseases [13]