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Nickel JC: Interstitial cystitis: A chronic pelvic pain syndrome

Peptides might be add-ons, not front line treatments

Given this finding we began examining Nle1- AngIV and found that as C-terminal amino acids were removed Ki decreased from 3.59 10-12 for Nle1-AngIV to 4.89 10-9 M for Nle1- tripeptide (Nle-Tyr-Ile)

This mechanism suggests the peptide can restore youthful patterns of gene expression in senescent cells