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This study included adults aged 18 years with obesity (BMI 30.0 kg/m 2 ) or overweight (BMI 27.029.9 kg/m 2 ) with at least one ORC (e.g., hypertension, T2D, dyslipidemia, obstructive sleep apnea, cardiovascular disease)

NAM pretreatment also promotes SIRT3 activation, maintaining the reduction in mitochondrial fission while restoring mitochondrial mass through improved autophagic flux

The two peptides are widely studied together in tissue-repair, gastrointestinal and cardiovascular injury models

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They enhance glucose-dependent insulin secretion , meaning the body is better able to release insulin when blood sugar rises