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The synergistic effect of combining hepsin with clinically low doses of NAC appeared to be more effective than the standard clinical care of high-dose NAC for APAP overdose

The concentration of CP in serum is 300450 g/mL and CP in cerebrospinal fluid is only 1 g/ mL 39 , and increased CP in different brain regions has been observed in NDs 40 , therefore, the role of CP in brain and its relationship with PD might be different

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Participants receiving 9 mg and 12 mg doses met all primary and key secondary endpoints

consequently, its discussion has been trimmed and moved to Future Directions, explicitly acknowledging the absence of clinical evidence and the PK uncertainties (dose, timing, BBB penetration, and formulation effects) relevant to rapid ascent scenarios

J Biol Chem, 1966