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Many practitioners recommend avoiding unnecessary actives during pregnancy and breastfeeding as a precautionary approach

Drug development research , 51 (2), 52-65

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Therefore, accordingly to their structural resemblance to proinsulin, they were finally renamed insulin-like growth factor I and II (IGF-I and II), molecules that also fulfill all the criteria of a somatomedin: 1) they possess insulin-like activity in the presence of insulin antibodies[3, 9]

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