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This mechanism is largely route-independent at the cellular level, which is why it is invoked for both topical and injectable use but a shared mechanism does not by itself prove that either route produces a visible skin outcome

Q., Menner A., Kay C

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J Neurochem 139(Suppl 2):136153 Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, Lange F, Andersson JLR, Griffanti L, Duff E, Jbabdi S, Taschler B, Keating P, Winkler AM, Collins R, Matthews PM, Allen N, Miller KL, Nichols TE, Smith SM (2022) SARS-COV-2 is associated with changes in brain structure in uk biobank

Therefore, further clinical trials are necessary to validate their therapeutic efficacy