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However, injectable vitamin B12, often prescribed to treat serious deficiencies, can cause the following side effects: mild diarrhea itching skin rash headache dizziness nausea vomiting pulmonary edema and congestive heart failure early in treatment vein thrombosis sensation of swelling polycythemia vera (rare, slow-growing blood cancer) Moreover, in rare cases, vitamin B12 can cause serious allergic reactions (anaphylaxis)

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The authors noted NNMT overexpression in many human malignancies and described 5-Amino-1MQ as a novel NNMT inhibitor with promising results across obesity and cancer cell research models

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While peptide therapy may possess significant therapeutic and regenerative potential, it is critical that orthopedic and sports medicine providers understand the current lack of evidence to support the clinical use of these peptides, the authors concluded