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Although all isoforms promote excitatory synaptic transmission, their subcellular localization varies significantly, with NLGN3 diffusely distributed in dendrites and NLGN3A1A2 enriched in spines, revealing that splicing-dependent isoform distribution specificity is a key molecular mechanism for bidirectional regulation of inhibitory synapses (85)

JCI Insight 7, e159863

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