Figure 6 3.8 CB-839 did not improve cytotoxicity in combination with venetoclax, AZD-5991, and ibrutinib in primary CLL lymphocytes We then tested these drug combinations in the primary CLL cells, both in the native condition ( Figure 7A ) and in media supplemented with cytokines (CD40 ligand and interleukin-4) to mimic the microenvironment and maintain viability ( Figure 7B )
[DOI] [PubMed] [Google Scholar] 36.Carroll A.R., Copp B.R., Davis R.A., Keyzers R.A., Prinsep M.R
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Richie: Yes, supplementation is an effective way to help maintain optimal levels of GSH in our cells and tissues
Were specifically looking at how amino acids regulate alpha cell biology. We have some molecular triggers that can activate GLP-1 production in the alpha cells and are conducting studies where we dose mice with different amino acids acutely to see how that affects the islet. The results so far are mind blowing, says Cummings
