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However, high doses ( 0.5 mg/kg/d) may activate the SREBP-1c pathway, increase liver fat synthesis, and lead to hypertriglyceridemia and fatty liver

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More specifically, Glp1r knockout mice display an altered composition of their intestinal microbiota (50)

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The combined effect is better blood sugar control and a significant reduction in appetite, leading to decreased food intake and, often, weight loss

TB-500 is not FDA-approved for veterinary use, so its sold as a research compound and doesnt require a traditional prescription