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It is the most widely studied tissue repair peptide in the preclinical literature
Clinical biomarker studies have produced heterogeneous associations between circulating irisin levels and indices of metabolic health, exercise capacity, and bone density across different populations, with effect sizes and directions varying by sex, age, and comorbidity status (Perakakis et al., 2017)
Similarly, the binding site of citalopram (Figure 3, left panel, bottom row) is composed of hydrophobic, polar, and charged residues
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