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The microdose approach reduces side effects like nausea while still triggering meaningful appetite suppression and weight reduction, making it ideal for step-wise treatment initiation
An apparent paradox is that whereas GLP-1 increases glucose-stimulated insulin secretion in the isolated pancreas fulfilling the definition of an incretin but it lowers insulin secretion in physiologically relevant conditions [6, 10, 18]
The global market for obesity drugs could increase by more than 15-fold by 2030 as their use expands beyond weight loss to treat a range of diseases
As of September 2025, GLP-1 prescriptions account for 6.5 out of every 100 prescriptions in the US
Nat Commun 17 , 5403 (2026)
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