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Thus, increased apoptosis during coronavirus infection contributes to increased tissue damage and pathogenesis of coronavirus infections

In addition to its metabolic functions, biotin may also influence gene regulation: it can attach to specific lysine residues on histone proteins (a process known as histone biotinylation), thereby potentially affecting chromatin structure and gene expression

1 results in an independent cohort

10.1038/sdata.2016.18 [DOI] [PMC free article] [PubMed] [Google Scholar] Winterbourn CC (2020) Hydrogen peroxide reactivity and specificity in thiol-based cell signalling

It translocates into the nucleus to regulate downstream targets, such as SLC7A11, GPX4, and NQO1

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