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An environment to nucleus signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation

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Pramlintide addresses amylin deficiency specifically accompanying beta-cell failurecomplementing insulin rather than replacing its secretory function

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In addition, the committee recommends the identification of biomarkers specifically related to proposed mechanisms of action for individual nutritional interventions