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Chem Biol Interact (2019) 310:108688
GEP44 interacts with GLP-1, Y1, and Y2 receptors to regulate insulin secretion in both rat and human pancreatic islets, and it promotes insulin-independent Y1-R-mediated glucose uptake in rat muscle tissue ex vivo
In order to maintain a redox state of equilibrium and prevent ferroptosis, the transcription factor Nrf2 is essential
Common adverse effects include nausea, vomiting, diarrhoea, and constipation, which often improve over time
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