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The first heart sound (S1) represents closure of the atrioventricular (mitral and tricuspid) valves as the ventricular pressures exceed atrial pressures at the beginning of systole (point a)

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Acta Physiol Hung 69:133138 Abella A, Clerc D, Chalas J et al (1987) Contration en superoxyde dismutase (cuivre et manganese) catalase et glutathion peroxydase dans les hematies, les plaquettes, et le plasma des sujets atteints de polyarthrite rhumatoide