In addition, two homologs, GGTLC1 (previously GGTL6, GGTLA4) and GGTLC2, which may only encode the light-chain portion of GGT, as well as at least three other homologs, exhibit activity: GGT5 (formerly GGL, GGTLA1/GGT-rel), GGT6 (formerly rat GGT6 homologous) and GGT7 (formerly GGTL3, GGT4) (28)
These interactions remain mechanistic hypotheses rather than confirmed pathways
Migraine, brain glucose metabolism and the Neuroenergetic hypothesis: a scoping review
Complementary items such as vitamins and specially formulated nootropic coffee are also available for related research
We speculate that this decrease in oxidative protein folding precludes excessive ROS load in the ER but at the expense of increased unfolded protein levels
[PubMed: 32773602] (Among 27 patients with fibromyalgia treated in a cross over trial of 5 week courses of ALA [600 mg daily] or placebo, symptoms of fibromyalgia and quality of life were similar in both treatment groups, as were adverse event rates)
