The Phase 3 ATTAIN-1 trial had good results that led to this approval, but not all positive: 12.4% average weight loss (27.3 lbs) at highest dose Lower than the 15-20% weight loss seen with injectables Wegovy and Zepbound Nearly 1/4 of participants on the highest dose reported vomiting Vomiting rates are much higher than injectable GLP-1s However, there is likely a niche for Foundayo (along with the pill version of Wegovy) due to convenience: No refrigeration requirements or injection site reactions Eliminates barriers for patients avoiding injectables due to stigma, needle aversion, or storage constraints It's possible we could see this as a "maintenance" therapy after an initial injectable course
When you and your doctor decide that Semaglutide is the right weight loss medication for you , you will need to take the medication regularly and follow a healthy diet and exercise regimen
They may return with a higher proportion of body fat and less muscle than before treatment , increasing the risk of long-term health complications
The combination of those agents increases the probability of adverse effects in patients with cirrhosis.113 In general, opioids should be avoided in cirrhotic patients
other authors support a potential anti-depressant effect of GLP-1RA, others a lack of association
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