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Basic research indicates that both PPAR and PGC1 stimulate CPT1A transcription by binding distinct regulatory regions within the CPT1A promoter (52)

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298 Overall, G9a has context-dependent effects: it suppresses autophagy through H3K9me1/2-mediated gene silencing in metabolic and tumor stress settings, whereas under nutrient deprivation or ischemia, it supports autophagy by repressing mTOR

Cleveland Clinic lists antidepressants as one option that can help with hot flashes and mood symptoms during perimenopause

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Lancet 352 , 15861589 (1998)