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In isolated mitochondria and in vitro Erv1 can transfer electrons either directly to oxygen or via cytochrome c and complex IV of the respiratory chain (Figure 7A)

The phenolic hydroxyl group derived from the tyrosine fragment may be sensitive to oxidative conditions

Although potential involvement of 3UTR cannot be excluded, we demonstrated that YBX1, which facilitates 5UTR-mediated HIF1A translation 38,46 , directly binds to the PRKAA1 5UTR and dictates AMPK1 protein synthesis

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