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The GLP-1 companion-supplement market was valued at roughly $735 million in the US in 2025 and is projected to keep growing at a double-digit annual rate through the early 2030s

If youre currently taking semaglutide or tirzepatide and want to understand how retatrutide compares, see our guide to retatrutide vs tirzepatide vs semaglutide

Centers for Disease Control and Prevention (CDC)

Even before reaching the liver, part of the dose may already be metabolized by intestinal enzymes such as CYP3A4 and UGTs, or pumped back into the intestinal lumen by efflux transporters like P-glycoprotein (ABCB1)

Rev Endocr Metab Disord 15 , 189196 (2014)

Semaglutide and orforglipron are pure GLP-1 agonists