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In 2019, Hu and co-workers showed a 4 fold increase in the delivery of methotrexate to rat brains by GSH-PEG liposomes when compared to that delivered by PEG control liposomes [47]

While such models provide significant mechanistic insights into APAP-induced hepatotoxicity, including pathways related to oxidative stress, mitochondrial dysfunction, and inflammasome activation, they may not fully recapitulate the complexity of human physiology

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The monitoring of vital signs and blood glucose levels enables medical, clinical, and nursing staff to closely observe patients and take necessary actions if there is any deterioration

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However, by interacting with mitochondrial complexes IV and V, ATP-binding cassette subfamily B member 7 reverses the above process when it is overexpressed [161]