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This degradation is not immediately visible, making adherence to storage guidelines critical for treatment reliability

doi: 10.4103/0974-8490.122917 189

The surface passivation reagents, including functional groups in molecules, are needed to prevent the nanoparticles from aggregation

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Jobbings CE, Sandig H, Whittingham-Dowd JK, Roberts IS, Bulfone-Paus S (2013) Listeria monocytogenes alters mast cell phenotype, mediator and osteopontin secretion in a listeriolysin-dependent manner