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7th Annual Oncology Update: Advances and Controversies

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Histamine intolerance implies impaired breakdown High histamine states may involve overproduction, mast cell activation, or inflammation Clues suggesting high histamine rather than simple intolerance: Symptoms unrelated to meals Nighttime anxiety or insomnia Sensory overstimulation Worsening with stress or hormonal shifts Clinical pattern recognition often matters more than isolated lab values

In TNBC patients, mRNA expression levels of OSGIN1, AKR1B10, SRXN1 and RGS17 were positively correlated with both worse RFS (hazard ratios 1.84, 1.51, 2.11, and 1.79, respectively) and with a worse DMFS (hazard ratios 2.49, 1.49, 2.08, and 2.09, respectively) (Fig

Its also needed for DNA repair, the formation of new red blood cells, and converting homocysteine to methionine

doi:10.1081/clt-200068842