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This is supported by Jun et al.s work demonstrating that ACN from gooseberry inhibited hepatic fibrosis by blocking the TGF-/Smad signaling pathway, and reduced the deposition of -smooth muscle actin (-SMA) protein and the expression of collagen I (Gao et al., 2020)
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Therefore both GST and efflux pumps overexpression may confer high levels of resistance to the cytotoxic action of several antineoplastic drugs
Immunotoxicity of organophosphorous pesticides
